The hotel is located in the downtown area of Santiago. Guests staying at the Hotel Plaza San Francisco will be able to visit the Government House and many national monuments in the area. The will also find places in the area that they can shop and dine. The Diego Portales Building, the Museum of Fine Arts and the opera house are all nearby. The highways are less than a mile from the property and the airport is only 13 miles away. Guests that do not have their own transportation will be able to use public transportation. Some sites that guests might want to visit are within walking distance of the Hotel Plaza San Francisco.

The Hotel Plaza San Francisco has 155 rooms that feature air conditioning, direct dial phones, data ports, cable TV, in room safe, wet bar, access to the Internet, and private bathrooms.

The hotel was originally built in 1989 and underwent renovation over the years. Guests of the Hotel Plaza San Francisco will find that the hotel offers an indoor swimming pool, exercise room, and restaurant as well.